Churubusco ; often shortened to Busco, is a town located near the headwaters of the Eel River in the extreme northeast corner of Whitley County, Indiana, United States, in Smith Township, about 16 miles (26 km) northwest of Fort Wayne. The population was 1,796 at the 2010 census.

The Eel River is a 94-mile-long (151 km) tributary of the Wabash River in northern Indiana in the United States. Via the Wabash and Ohio rivers, its waters flow to the Mississippi River and ultimately the Gulf of Mexico. The Eel River rises southeast of Huntertown in Allen County and flows southwest through Allen, Whitley, Kosciusko, Wabash, Miami, and Cass counties to join the Wabash at Logansport. The river was called Kineepikwameekwa Siipiiwi - "river of the snake fish" by the Miami people, who inhabited the area at the time of European contact, the English rendered it as Ke-na-po-co-mo-co. It is the northern of the two rivers named Eel River within Indiana.