The Cincinnati riot of 1853 was triggered by the visit of then-Archbishop Gaetano Bedini, the emissary of Pope Pius IX, to Cincinnati, Ohio, on 21 December 1853. The German Liberal population of the city, many of whom had come to America after the Revolutions of 1848, identified Cardinal Bedini with their reactionary opponents. An armed mob of about 500 German men with 100 women following marched on the home of Bishop John Purcell, protesting the visit. One protester was killed and more than 60 were arrested.

Gaetano Bedini was an Italian ecclesiastic, cardinal, and diplomat of the Catholic Church.