Cisco is a city in Eastland County, Texas, United States. The population was 3,899 at the time of the 2010 census.

Conrad Nicholson Hilton was an American businessman who founded the Hilton Hotels chain. From 1912 to 1916, Hilton was a Republican representative in the first New Mexico Legislature, but became disillusioned with the "inside deals" of politics. In 1919, he purchased his first hotel, the Mobley Hotel in Cisco, Texas, for $40,000, and subsequently capitalized on the oil boom. The rooms were rented out in eight-hour shifts. He continued to buy and sell hotels, and eventually established the world's first international hotel chain. When he died in 1979, he left the bulk of his estate to the Conrad N. Hilton Foundation.