Ciudad Obregón is a city in southern Sonora. It is the state's second largest city after Hermosillo and serves as the municipal seat of Cajeme. As of 2020, the city has a population of 436,484. Ciudad Obregón is 530 km (330 mi) south of the state's northern border.

Sonora, officially Estado Libre y Soberano de Sonora, is one of the 31 states which, along with Mexico City, comprise the Federal Entities of Mexico. The state is divided into 72 municipalities; the capital city of which being Hermosillo, located in the center of the state. Other large cities include Ciudad Obregón, Nogales, San Luis Río Colorado, and Navojoa.