Claiborne Avenue is a major thoroughfare in New Orleans, Louisiana. It runs the length of the city, about 9.5 miles (15.3 km), beginning at the Jefferson Parish line and ending at the St. Bernard Parish line; the street continues under different names in both directions. It is called South Claiborne Avenue upriver from Canal Street and North Claiborne Avenue from Canal to St. Bernard Parish.

William Charles Cole Claiborne was an American politician, best known as the first non-colonial governor of Louisiana. He also has the distinction of possibly being the youngest member of the United States Congress in U.S. history, although reliable sources differ about his age.