Clarendon is a city in, and the county seat of, Monroe County, Arkansas, United States. Located in the Arkansas Delta, the city's position on the White River at the mouth of the Cache River has defined the community since first incorporating in 1859. Although the river has brought devastation and disaster to the city occasionally throughout history, it has also provided economic opportunities, transportation, recreation and tourism to the city.

Monroe County is located in the Arkansas Delta in the U.S. state of Arkansas. The county is named for James Monroe, the fifth President of the United States. Created as Arkansas's 20th county on November 2, 1829, Monroe County is home to two incorporated towns and three incorporated cities, including Clarendon, the county seat, and Brinkley, the most populous city. The county is also the site of numerous unincorporated communities and ghost towns.