Clarke County is a county located in the U.S. state of Mississippi. As of the 2020 census, the population was 15,615. Its county seat is Quitman. Clarke County is named for Joshua G. Clarke, the first Mississippi state chancellor and judge.

Quitman is a city in Clarke County, Mississippi, United States, along the Chickasawhay River. The population was 2,323 at the 2010 census. Quitman is the county seat of Clarke County.