Clarksville is a town in Mecklenburg county in the U.S. state of Virginia, near the southern border of the commonwealth. The population was 1,139 at the 2010 census. Since the town has numerous buildings of the 18th-, 19th-, and early 20th-century architecture, the downtown area of Clarksville has been designated a Historic District on the National Register of Historic Places and Virginia's Historic Register. Clarksville claims the title of Virginia's only Lakeside town. Nearby the town of Clarksville is Occoneechee State Park.

Mecklenburg County is a county in the Commonwealth of Virginia. As of the 2020 census, the population was 30,319. Its county seat is Boydton.