Class of Nuke 'Em High is a 1986 American science-fiction horror comedy film produced and distributed by Troma Entertainment. Directed by Richard W. Haines and Lloyd Kaufman, the film follows a high school impacted by radioactive drugs obtained from a nearby nuclear power plant.

Troma Entertainment is an American independent film production and distribution company founded by Lloyd Kaufman and Michael Herz in 1974. The company produces low-budget independent films, or "B movies", primarily of the horror comedy genre, all geared exclusively to mature audiences. Many of them play on 1950s horror with elements of farce, parody, gore, and splatter.