Fra' Claude de la Sengle was the 48th Grand Master of the Order of Malta, from 1553 to his death in 1557. His successor was Fra' Jean Parisot de Valette.

Fra' Jean "Parisot" de (la) Valette was a French nobleman and 49th Grand Master of the Order of Malta, from 21 August 1557 to his death in 1568. As a Knight Hospitaller, joining the order in the Langue de Provence, he fought with distinction against the Turks at Rhodes. As Grand Master, Valette became the Order's hero and most illustrious leader, commanding the resistance against the Ottomans at the Great Siege of Malta in 1565, sometimes regarded as one of the greatest sieges of all time.