Clay Junior-Senior High School is a public high school in Clay Township, Ohio, United States, located four miles (6 km) north of the Portsmouth in Scioto County. It is the only high school in the Clay Local School District. Clay is a rural high school serving about 300 students in grades 7–12 in Southern Ohio. The first class graduated in 1940.

The Clay Local School District (CLSD) is located four miles (6.4 km) north of the Portsmouth, Ohio, city limits on U.S. Route 23 in Clay Township in Scioto County—which is 85 miles (137 km) south of Columbus, Ohio; 50 miles (80 km) west of Huntington, West Virginia; and 100 miles (160 km) east of Cincinnati, Ohio. Clay is a rural Ohio public school district serving 700 students in grades pre-K through 12 in Southern Ohio. With the creation of a high school (Clay Township High School) for the district in 1940, students for the first time were able to graduate from a Clay Local School District building.