Claydon House is a country house in the Aylesbury Vale, Buckinghamshire, England, near the village of Middle Claydon. It was built between 1757 and 1771 and is now owned by the National Trust.

The Aylesbury Vale is a geographical region in Buckinghamshire, England, which is bounded by the City of Milton Keynes and West Northamptonshire to the north, Central Bedfordshire and the Borough of Dacorum (Hertfordshire) to the east, the Chiltern Hills to the south and South Oxfordshire to the west. It is named after Aylesbury, the county town of Buckinghamshire. Winslow and Buckingham are among the larger towns in the vale.