Cleopatra Selene was the Queen consort of Egypt from 115 to 102 BC, the Queen consort of Syria from 102 to 92 BC, and the monarch of Syria from 82 to 69 BC. The daughter of Ptolemy VIII Physcon and Cleopatra III of Egypt, Cleopatra Selene was favoured by her mother and became a pawn in Cleopatra III's political manoeuvres. In 115 BC, Cleopatra III forced her son Ptolemy IX to divorce his sister-wife Cleopatra IV, and chose Cleopatra Selene as the new queen consort of Egypt. Tension between the king and his mother grew and ended with his expulsion from Egypt, leaving Cleopatra Selene behind; she probably then married the new king, her other brother Ptolemy X.

Ptolemy VIII Euergetes II Tryphon, nicknamed Physcon, was a king of the Ptolemaic dynasty in Egypt. He was the younger son of King Ptolemy V and Queen Cleopatra I. His reign was characterised by fierce political and military conflict with his older siblings, Ptolemy VI and Cleopatra II.