Cleveland Central Catholic High School is a private co-educational high school located in Cleveland, Ohio. It is run by the Roman Catholic Diocese of Cleveland. It is a member of the North Central Association, the Notre Dame Education Association, and the National Catholic Education Association.

The Diocese of Cleveland is a Latin Church ecclesiastical territory, or diocese, of the Catholic Church in northeastern Ohio in the United States. As of September 2020, the bishop is Edward Malesic. The Cathedral of St. John the Evangelist, located in Cleveland, is the mother church of the diocese.