Cleveland Clinic is an American nonprofit academic medical center based in Cleveland, Ohio. Owned and operated by the Cleveland Clinic Foundation, an Ohio nonprofit corporation, Cleveland Clinic was founded in 1921 by a group of faculty and alumni from the Case Western Reserve University School of Medicine. The Clinic runs a 170-acre (69-hectare) main campus in Cleveland, as well as 14 affiliated hospitals, 20 family health centers in Northeast Ohio, 5 affiliated hospitals in Florida, and cancer center in Nevada. International operations include the Cleveland Clinic Abu Dhabi hospital in the United Arab Emirates and Cleveland Clinic Canada, which has two executive health and sports medicine clinics in Toronto. Another hospital campus in the United Kingdom, Cleveland Clinic London, opened to outpatients in 2021 and fully opened in 2022. Tomislav Mihaljevic is the president and CEO.

An academic medical centre (AMC), variously also known as academic health science centre, academic health science system, or academic health science partnership, is an educational and healthcare institute formed by the grouping of a health professional school with an affiliated teaching hospital or hospital network.