Cleveland Clinic is an American nonprofit academic medical center based in Cleveland, Ohio. Owned and operated by the Cleveland Clinic Foundation, an Ohio nonprofit corporation, Cleveland Clinic was founded in 1921 by a group of faculty and alumni from the Case Western Reserve University School of Medicine. The Clinic runs a 170-acre (69-hectare) main campus in Cleveland, as well as 14 affiliated hospitals, 20 family health centers in Northeast Ohio, 5 affiliated hospitals in Florida, and cancer center in Nevada. International operations include the Cleveland Clinic Abu Dhabi hospital in the United Arab Emirates and Cleveland Clinic Canada, which has two executive health and sports medicine clinics in Toronto. Another hospital campus in the United Kingdom, Cleveland Clinic London, opened to outpatients in 2021 and fully opened in 2022. Tomislav Mihaljevic is the president and CEO.

Cleveland State University (CSU) is a public research university in Cleveland, Ohio, United States. It was established in 1964 and opened for classes in 1965 after acquiring the entirety of Fenn College, a private school that had been in operation since 1923. CSU absorbed the Cleveland-Marshall School of Law in 1969. Today it is part of the University System of Ohio, has more than 120,000 alumni, and offers over 200 academic programs amongst eight colleges. It is classified among "R2: Doctoral Universities – High research activity".