Clifton is a city in Wayne County, Tennessee, on the state's south central border with Alabama. It developed as a river port along the Tennessee River in the 19th century. Its historic districts listed on the National Register of Historic Places are associated with this period. The population was 2,694 at the 2010 census.

Wayne County is a county located in south central Tennessee, along the Alabama border. As of the 2020 census, the population was 16,232. Its county seat is Waynesboro. The county is named after General "Mad Anthony" Wayne, a prominent military leader in the American Revolutionary War.