Clifton Forge is a town in Alleghany County, Virginia, United States which is part of the greater Roanoke Region. The population was 3,555 at the 2020 census. The Jackson River flows through the town, which as a result was once known as Jackson's River Station.

U.S. Route 60 (US 60) in the Commonwealth of Virginia runs 303 miles (488 km) west to east through the central part of the state, generally close to and paralleling the Interstate 64 corridor, except for the crossing of the Blue Ridge Mountains, and in the South Hampton Roads area.