The Clinton Power Station is a nuclear power plant located near Clinton, Illinois, USA. The power station began commercial operation on November 24, 1987 and has a nominal net electric output of 1062 MWe. Due to inflation and cost overruns, Clinton's final construction cost was $4.25 billion, nearly 1,000% over the original budget of $430 million and seven years behind schedule.

Clinton is the largest city in DeWitt County, Illinois, United States. The population was 7,004 at the 2020 census. It is the county seat of DeWitt County.