Clio is a city in Barbour County, Alabama, United States. The population was 1,399 at the 2010 census, down from 2,206 in 2000, at which time it was a town. It is the birthplace of former Alabama governor George C. Wallace, as well as Baseball Hall of Famer and former Atlanta Braves broadcaster Don Sutton.

Barbour County is a county in the southeastern part of the U.S. state of Alabama. As of the 2020 census, the population was 25,223. Its county seat is Clayton. Its largest city is Eufaula. Its name is in honor of James Barbour, who served as Governor of Virginia.