Club Atlético Colón de Santa Fe, commonly referred to as Colón de Santa Fe, is a sports club from Santa Fe, Argentina. The football team plays in the second Division of the Argentine football league system, the Primera Nacional.

Santa Fe de la Vera Cruz is the capital city of the province of Santa Fe, Argentina. It is situated in north-eastern Argentina, near the junction of the Paraná and Salado rivers. It lies 15 kilometres (9.3 mi) from the Hernandarias Subfluvial Tunnel that connects it to the city of Paraná. The city is also connected by canal with the port of Colastiné on the Paraná River. Santa Fe de la Vera Cruz has about 391,164 inhabitants per the 2010 census [INDEC]. The metropolitan area has a population of 653,073, making it the eighth largest in Argentina.