The Clyde River is a main tributary which feeds the Seneca River in Seneca County, New York, United States. It begins at the hamlet of Lyons in nearby Wayne County and meanders for approximately 27 miles from west to east before emptying into the Seneca River in the town of Tyre at Montezuma National Wildlife Refuge. Much of the original river has been channeled through to form part of the Erie Canal. A number of tributaries feed the Clyde River along its route.

The Seneca River flows 61.6 miles (99.1 km) through the Finger Lakes region of Upstate New York in the United States. The main tributary of the Oswego River – the second-largest river flowing into Lake Ontario – the Seneca drains 3,468 square miles (8,980 km2) in parts of fourteen New York counties. The Seneca flows generally east, and is wide and deep with a gentle gradient. Much of the river has been channelized to form part of the Erie Canal.