Clymer is a town in Chautauqua County, New York, United States. The population was 1,748 at the 2020 census. The town is named for George Clymer, a signer of the Declaration of Independence. Clymer is located in the southwest part of the county.

George Clymer was an American politician, abolitionist and Founding Father of the United States, one of only six founders who signed both the Declaration of Independence and U.S. Constitution. Clymer was among the earliest patriots to advocate for complete independence from Britain. He attended the Continental Congress and served in political office until the end of his life. He was a Framer of the Constitution where he attempted unsuccessfully to regulate the importation of slaves. Clymer was himself a minor slave owner, at least briefly when seven years old through inheritance.