Coclé is a province of central Panama on the nation's southern coast. The administrative capital is the city of Penonomé. This province was created by the Act of September 12, 1855 with the title of Department of Coclé during the presidency of Dr. Justo de Arosemena. It became a province, Decretory Number 190, on October 20, 1985. Coclé is primarily an agricultural area, with sugar and tomatoes as major crops. The province has a number of well-known beaches, such as Santa Clara, Farallon and Rio Hato, and tourist activity has increased in recent years. It covers an area of 4,946.6 km2, and had a population of 268,264 in 2023.

Penonomé is the capital of the Panamanian province of Coclé. The town is located in the geographic center of Panama along the Inter-American Highway in the wide, flat lowlands of central Coclé.