Coeburn is a town in Wise County, Virginia, United States, along the Guest River. The population was 2,139 at the 2010 census.

Wise County is a county located in the U.S. state of Virginia. The county was formed in 1856 from Lee, Scott, and Russell Counties and named for Henry A. Wise, who was the Governor of Virginia at the time. The county seat is in Wise.