Cohoba is a Taíno transliteration for a ceremony in which the ground seeds of the cojóbana tree were inhaled, the Y-shaped nasal snuff tube used to inhale the substance, and the psychoactive drug that was inhaled. Use of this substance produced a hallucinogenic, entheogenic, or psychedelic effect. The cojóbana tree is believed by some to be Anadenanthera peregrina although it may have been a generalized term for psychotropics, including the quite toxic Datura and related genera (Solanaceae). The corresponding ceremony using cohoba-laced tobacco is transliterated as cojibá. This was said to have produced the sense of a visionary journey of the kind associated with the practice of shamanism.

The Taíno were a historic Indigenous peoples of the Caribbean, whose culture has been continued today by Taíno descendant communities and Taíno revivalist communities. At the time of European contact in the late 15th century, they were the principal inhabitants of most of what is now Cuba, the Dominican Republic, Jamaica, Haiti, Puerto Rico, the Bahamas, and the northern Lesser Antilles. The Lucayan branch of the Taíno were the first New World peoples encountered by Christopher Columbus, in the Bahama Archipelago on October 12, 1492. The Taíno spoke a dialect of the Arawakan language group. They lived in agricultural societies ruled by caciques with fixed settlements and a matrilineal system of kinship and inheritance. Taíno religion centered on the worship of zemis.