Colón is a city and seaport in Panama, beside the Caribbean Sea, lying near the Atlantic entrance to the Panama Canal. It is the capital of Panama's Colón Province and has traditionally been known as Panama's second city. Originally it was located entirely on Manzanillo Island, surrounded by Limon Bay, Manzanillo Bay, and the Folks River; however, since the disestablishment of the Panama Canal Zone, the city's limits have been redefined to include Fort Gulick, a former U.S. Army base, as well as the former Panama Canal Zone towns of Cristobal, Margarita, and Coco Solo.

Panama, officially the Republic of Panama, is a country in Latin America at the southern end of Central America, bordering South America. It is bordered by Costa Rica to the west, Colombia to the southeast, the Caribbean Sea to the north, and the Pacific Ocean to the south. Its capital and largest city is Panama City, whose metropolitan area is home to nearly half the country's over 4 million inhabitants.