Colón is a city and seaport in Panama, beside the Caribbean Sea, lying near the Atlantic entrance to the Panama Canal. It is the capital of Panama's Colón Province and has traditionally been known as Panama's second city. Originally it was located entirely on Manzanillo Island, surrounded by Limon Bay, Manzanillo Bay, and the Folks River; however, since the disestablishment of the Panama Canal Zone, the city's limits have been redefined to include Fort Gulick, a former U.S. Army base, as well as the former Panama Canal Zone towns of Cristobal, Margarita, and Coco Solo.

William Henry Aspinwall was a prominent American businessman who was a partner in the merchant firm of Howland & Aspinwall and was a co-founder of both the Pacific Mail Steamship Company and Panama Canal Railway companies which revolutionized the migration of goods and people to the Western coast of the United States.