The Col. Frank J. Hecker House is a historic home in Detroit built in 1888 for local businessman and railroad-car manufacturer Colonel Frank J. Hecker. Located at 5510 Woodward Avenue, it was designated a Michigan State Historic Site in 1958. It is located near to the East Ferry Avenue Historic District and Cultural Center Historic District, and was listed on the National Register of Historic Places in 1971. The house has been owned by Wayne State University since September 2014.

The East Ferry Avenue Historic District is a historic residential district in Midtown Detroit, Michigan. The nationally designated historic district stretches two blocks from Woodward Avenue east to Brush Street; the locally designated historic district includes a third block between Brush and Beaubien. The district includes the separately designated Col. Frank J. Hecker House and the Charles Lang Freer House. It was designated a Michigan State Historic Site in 1976 and listed on the National Register of Historic Places in 1980.