Colbert County is a county located in the northwestern part of the U.S. state of Alabama. As of the 2020 census the county's population was 57,227. The county seat is Tuscumbia. The largest city is Muscle Shoals.

Tuscumbia is a city in, and the county seat of, Colbert County, Alabama, United States. As of the 2020 census, the population was 9,054. The city is part of The Shoals metropolitan area.