Collis Potter Huntington was an American industrialist and railway magnate. He was one of the Big Four of western railroading who invested in Theodore Judah's idea to build the Central Pacific Railroad as part of the first U.S. transcontinental railroad. Huntington helped lead and develop other major interstate lines, such as the Southern Pacific Railroad and the Chesapeake & Ohio Railway (C&O), which he was recruited to help complete. The C&O, completed in 1873, fulfilled a long-held dream of Virginians of a rail link from the James River at Richmond to the Ohio River Valley. The new railroad facilities adjacent to the river there resulted in expansion of the former small town of Guyandotte, West Virginia into part of a new city which was named Huntington in his honor.

"The Big Four" was the name popularly given to the famous and influential businessmen, philanthropists and railroad tycoons who funded the Central Pacific Railroad (C.P.R.R.), which formed the western portion through the Sierra Nevada and the Rocky Mountains of the First Transcontinental Railroad in the United States, built from the mid-continent at the Missouri River to the Pacific Ocean during the middle and late 1860s.