Colombia first formally participated at the Olympic Games in 1932, and has sent athletes to compete in all but one edition of the Summer Olympic Games since then, missing only the 1952 Games. Colombian athletes have won a total of 34 Olympic medals in eight different sports, with weightlifting and cycling as the most successful ones. Colombia is the third most successful South American country at the Olympic Games, after Brazil and Argentina respectively. The Colombian Olympic Committee was created in 1936 and recognised by the International Olympic Committee in 1948.

Colombia competed at the 2012 Summer Olympics in London, from 27 July to 12 August 2012. This was the nation's eighteenth appearance at the Olympics, having not competed at the 1952 Summer Olympics in Helsinki.