The Colombian Constitution of 1886 was the constitution that remade the United States of Colombia into the Republic of Colombia, and replaced the federal republic with a unitary state. Following the Colombian Civil War (1884–1885), a coalition of moderate Liberals and Conservatives, led by Rafael Nuñez, ended the political period known as "the Radical Olympus", repealed the Constitution of Rionegro (1863), and substituted it with the constitution of 1886. From then on, the country was officially known as the Republic of Colombia. The Constitution of 1886 was the longest lasting constitution in the history of Colombia, eventually being itself replaced by the Constitution of 1991.

Rafael Wenceslao Núñez Moledo was a Colombian author, lawyer, journalist and politician, who was elected president of Colombia in 1880 and in 1884. Núñez was the leader of the so-called "Regeneration" process which produced the Colombian Constitution of 1886 which was to remain until 1991.