The Colombo crime family is an Italian American Mafia crime family and is the youngest of the "Five Families" that dominate organized crime activities in New York City within the criminal organization known as the American Mafia. It was during Lucky Luciano's organization of the American Mafia after the Castellammarese War, following the assassinations of "Joe the Boss" Masseria and Salvatore Maranzano, that the gang run by Joseph Profaci became recognized as the Profaci crime family.

The American Mafia, commonly referred to in North America as the Italian-American Mafia, the Mafia, or the Mob, is a highly organized Italian American criminal society and organized crime group.