The Colorado River Delta is the region where the Colorado River flows into the Gulf of California in eastern Mexicali Municipality in the north of the state of Baja California in northwesternmost Mexico. The delta is part of a larger geologic region called the Salton Trough. Historically, the interaction of the river's flow and the ocean's tide created a dynamic environment, supporting freshwater, brackish, and saltwater species. Within the delta region, the river split into multiple braided channels and formed a complex estuary and terrestrial ecosystems. The use of water upstream and the accompanying reduction of freshwater flow has resulted in the loss of most of the wetlands of the area, as well as drastic changes to the aquatic ecosystems. However, a scheme is currently in place which aims to rejuvenate the wetlands by releasing a pulse of water down the river delta.

The Colorado River is one of the principal rivers in the Southwestern United States and in northern Mexico. The 1,450-mile-long (2,330 km) river, the 5th longest in the United States, drains an expansive, arid watershed that encompasses parts of seven U.S. states and two Mexican states. The name Colorado derives from the Spanish language for "colored reddish" due to its heavy silt load. Starting in the central Rocky Mountains of Colorado, it flows generally southwest across the Colorado Plateau and through the Grand Canyon before reaching Lake Mead on the Arizona–Nevada border, where it turns south toward the international border. After entering Mexico, the Colorado approaches the mostly dry Colorado River Delta at the tip of the Gulf of California between Baja California and Sonora.