On November 19–20, 2022, an anti-LGBT-motivated mass shooting occurred at Club Q, a gay bar in Colorado Springs, Colorado, United States. Five people were murdered, and 25 others were injured, 19 of them by gunfire. The shooter, 22-year-old Anderson Lee Aldrich, was also injured while being restrained, and was taken to a local hospital. Aldrich was then charged and remanded in custody. On June 26, 2023, Aldrich pled guilty to the shooting and was officially sentenced to a total of 5 whole consecutive back-to-back life terms plus an additional consecutive 2,211 years all of it without the possibility of parole. On January 16, 2024, Aldrich was additionally charged with 50 federal hate crimes in connection with the shooting.

On May 14, 2022, a mass shooting occurred in Buffalo, New York, United States, at a Tops Friendly Markets supermarket in the East Side neighborhood. Ten people, all of whom were African Americans, were murdered and three were injured. The shooter, identified as 18-year-old Payton S. Gendron, livestreamed part of the attack on Twitch, but the livestream was shut down by the service in under two minutes. Gendron was taken into custody and charged with first-degree murder. He formally entered a plea of "not guilty" on May 19, 2022. On November 28, 2022, Gendron pleaded guilty to all state charges in the shooting, including murder, domestic terrorism, and hate crimes. On February 15, 2023, Gendron was sentenced to 11 consecutive life sentences without the possibility of parole; as of that date, federal charges are still ongoing, and the federal prosecution also expressed their intention to seek the death penalty.