Colt .45 is an American Western television series, originally starring Wayde Preston, which aired on ABC between October 1957 and September 1960.

Television Westerns are programs with settings in the later half of the 19th century in the American Old West, Western Canada and Mexico during the period from about 1860 to the end of the so-called "Indian Wars". More recent entries in the Western genre have used the neo-Western subgenre, placing events in the modern day, or the space Western subgenre but still draw inspiration from the outlaw attitudes prevalent in traditional Western productions.