Columbia Regional Airport is a commercial passenger airport serving Columbia, Missouri. Located about 12 miles (19 km) southeast of Columbia in Boone County, Missouri, it is the only commercial airport in Mid-Missouri and also serves the state capital of Jefferson City. As of 2022, commercial passenger service is provided by American Airlines subsidiary American Eagle. The airport opened in 1968, replacing the Columbia Municipal Airport off of Interstate 70. It is frequently used for charter flights by college athletic teams visiting the University of Missouri and for MU team flights.

Columbia is a city in the U.S. state of Missouri. It is the county seat of Boone County and home to the University of Missouri. Founded in 1821, it is the principal city of the three-county Columbia metropolitan area. It is Missouri's fourth most populous with an estimated 128,555 residents in 2022.