Columbine is a census-designated place (CDP) in and governed by Jefferson and Arapahoe counties in Colorado, United States. The CDP is a part of the Denver metropolitan area. Located primarily in Jefferson County, Columbine lies immediately south of Denver. The population of the Columbine CDP was 25,229 at the 2020 census. The community lies in ZIP code 80123.

Jefferson County is a county located in the U.S. state of Colorado. As of the 2020 census, the population was 582,910, making it the fourth-most populous county in Colorado. The county seat is Golden, and the most populous city's Lakewood.