Columbus is a home rule-class city in Hickman County, Kentucky, in the United States. The population was 140 at the 2020 census, a decline from 229 in 2000. The city lies at the western end of the state, less than a mile from the Mississippi River.

Hickman County is a county located in the U.S. state of Kentucky. As of the 2020 census, the population was 4,521, making it the third-least populous county in Kentucky. Its county seat is Clinton. The county was formed in 1821. It is the least densely populated county in the state and is a prohibition or dry county.