Comacchio is a town and comune of Emilia Romagna, Italy, in the province of Ferrara, 48 kilometres (30 mi) from the provincial capital Ferrara. It was founded about two thousand years ago; across its history it was first governed by the Exarchate of Ravenna, then by the Duchy of Ferrara, and eventually returned to be part of the territories of the Papal States. For its landscape and its history, it is considered one of the major centres of the Po delta.

The province of Ferrara is a province in the Italian region of Emilia-Romagna. Its capital is the city of Ferrara. As of May 2023, it has a population of 338,143 inhabitants over an area of 2,635.12 square kilometres (1,017.43 sq mi). The province contains 23 comuni, listed in the list of comuni of the province of Ferrara. Its provincial president is Gianni Michele Padovani.