Combe Sydenham is an historic manor in Somerset, England. The 15th-century manor house, called Combe Sydenham House is in the parish of Stogumber, Somerset and is situated just within the boundary of Exmoor National Park. It is a Grade I listed building.

Stogumber is a village and civil parish in Somerset, England, on the eastern flank of the Brendon Hills. Besides Stogumber village itself, the parish includes the hamlets of Ashbeer, Capton, Escott, Higher Vexford, Kingswood, Lower Vellow, Lower Vexford, Preston, and Vellow. The village is on the route of the Samaritans Way South West.