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Combretum indicum

Combretum indicum known as the Rangoon creeper or Chinese honeysuckle, is a vine with red flower clusters and native to tropical Asia. It is not related to the true honeysuckle species Lonicera tragophylla, called the Chinese honeysuckle; the Rangoon creeper is a ligneous vine. The leaves are elliptical with a rounded base, they grow from 7 to 15 centimeters and their arrangement is opposite. The flowers are fragrant and tubular and their color varies from white to pink to red; the 30 to 35 mm long fruit has five prominent wings. The fruit tastes like almonds. Rangoon creeper is found in thickets or secondary forests of the Philippines and Malaysia, it has since been cultivated and naturalized in tropical areas such as Burma and Thailand. The flowers change in colour with age and it is thought that this is a strategy to gather more pollinators; the flower is white and opens at dusk. This attracts hawkmoths with long tongues for pollination. On the second day it turns pink and on the third it turns red attracting day flying bees and birds.

The flower changes from a horizontal orientation to a drooping pose. The plant is used as an herbal medicine. Decoctions of the root, seed or fruit can be used as antihelmintic to expel parasitic worms or for alleviating diarrhea. Fruit decoction can be used for gargling; the fruits are used to combat nephritis. Leaves can be used to relieve pain caused by fever; the roots are used to treat rheumatism. The seeds of this and related species, Quisqualis fructus and Q. chinensis, contain the chemical quisqualic acid, an agonist for the AMPA receptor, a kind of glutamate receptor in the brain. The chemical is linked to excitotoxicity; the seeds from the pod are useful for treating Pinworm. It kills it in the digestive tract. Dr John Ivor Murray sent a sample of the "nuts" to the Museum of Economic Botany in Edinburgh in 1861, with a note that they were "used by the Chinese for worms" and a description of the means of preparation and dosage. QUISQUALIS INDICA Linn niyog-niyogan.doc Quisqualis indica L. Quisqualis indica Madhumalati Dressler, S..

"Combretum indicum". African plants – a Photo Guide. Frankfurt/Main: Forschungsinstitut Senckenberg

1969 Italian Open (tennis)

The 1969 Italian Open was a combined men's and women's tennis tournament, played on outdoor clay courts at the Foro Italico in Rome, Italy. It was the 26th edition of the tournament and the first, open to amateur and professional players; the event finished a day late. The singles titles were won by second-seeded John Newcombe and Julie Heldman, the first American female player to win the title in 13 years. John Newcombe defeated Tony Roche 6–3, 4–6, 6–2, 5–7, 6–3 Julie Heldman defeated Kerry Melville 7–5, 6–3 Tom Okker / Marty Riessen defeated John Newcombe / Tony Roche 4–6, 6–1, susp Françoise Dürr / Ann Haydon-Jones defeated Rosemary Casals / Billie Jean King 6–3, 3–6, 6–2 International Tennis Federation – Tournament details Association of Tennis Professionals – Tournament profile Official tournament website

Michel Nischan

Michel Nischan is a chef and leader in the sustainable food movement, as well as a four-time James Beard Foundation Award winner. He is Founder, President and CEO of Wholesome Wave, Co-Founder of the Chefs Action Network, as well as Founder and Partner with the late actor Paul Newman of the former Dressing Room Restaurant, he and his Wholesome Wave team were successful at influencing legislative language for the passed Federal Farm Bill, supporting affordable access to healthy, locally grown fruits and vegetables for low income consumers. Wholesome Wave was founded in 2007 by Nischan, along with friends Michael Batterberry, Gus Schumacher as founding Board Chair, it was founded with funding from Newman’s Own Foundation and the Betsy and Jesse Fink Foundation, supported in part by funding from Grow for Good, a philanthropic initiative of FOOD & WINE Magazine. The mission of Wholesome Wave is to empower underserved Americans to make healthier food choices by providing affordable access to fruits and vegetables at farmers markets and grocery retailers.

Until Dressing Room closed in 2014, Wholesome Wave and Dressing Room worked in tandem to create grassroots initiatives that celebrate local food systems, affordable food access in urban and rural communities struggling with poverty, heritage recipe restoration. Nischan’s most cookbook Sustainably Delicious, was released in April, 2010, he is the author of two other celebrated cookbooks: Taste Pure and Simple, a 2004 best-selling Beard award winner, Homegrown Pure and Simple. Nischan’s book Taste Pure and Simple won a James Beard Foundation Award in 2004. Nischan won a second Beard Award in 2008 for his work on the PBS television series Victory Garden, his most recent award was presented by the James Beard Foundation in May 2015 for Humanitarian of the Year. He is an Ashoka fellow. Nischan serves on the boards of the Amazon Conservation Team, the James Beard Foundation and Harvard’s Center for Health and the Global Environment. Below is a full list of his awards: 2016 James Beard Foundation, WHo's Who in Food and Beverage 2015 James Beard Foundation, Humanitarian of the Year 2015 Children of Bellevue, Honoree 2013 Food Inc.

Awards, Pioneer Award 2013 Ira V. Hisckock Award for Public Health Service 2013 American Heart Association, Change the Future Award 2012 Monterey Bay Aquarium, Sustainable Chef of the Year 2012 Utne Reader Visionary Award 2012 California Small Farm Coalition Award for Excellence 2011 International Association of Culinary Professionals, Humanitarian of the Year 2010 Hummingbird Environmental Citizen Award 2010 Chefs Collaborative, Pioneers Table Award 2010 Diabetes Research Institute, Dare to Dream Award 2010 Huffington Post, Top 100 Game Changer’s Award 2010 Lifetime Ashoka Fellowship Award 2008 Marine Stewardship Council, Sustainable Seafood Ambassador Award 2008 James Beard Foundation, Best Television Segment for PBS “Victory Garden” 2007 Food Arts Magazine, Silver Spoon Award 2007 American Heart Association, Chef with Heart Award 2007 Condé Nast Traveler, Top 95 Restaurants in the World: Dressing Room Restaurant in Westport, CT and Pure Restaurant in Mumbai, India 2007 Esquire Asia, Top 10 New Restaurants in the World: Pure Restaurant, Mumbai India 2004 James Beard Foundation, Best Health Focused Cookbook 2004 Physician’s Committee for Responsible Medicine – Best Airline Food, Song Airways Food for Sale Program 1988 Marriott Hotels Corporation Chef of the Year A son of displaced farmers, Nischan grew up with a deep appreciation for sustainable agriculture and those who work the land.

As a professional chef and advocate for a more healthful and sustainable food future, he has built on those childhood values and become a catalyst for change and new initiatives in local and regional food systems. Wholesome Wave Michel Nischan The James Beard Foundation


GTx-758 is a synthetic nonsteroidal estrogen, under development by GTx, Inc. for the treatment of advanced prostate cancer. As of 2016, it has completed two phase II clinical trials. GTx-758 acts as a selective agonist of the estrogen receptor, with a more than 10-fold preference for activation of ERα relative to ERβ; the selectivity of GTx-758 for ERα over ERβ may confer reduced hypercoagulability and thrombophilia, as estradiol directly produces these effects in platelets via activation of ERβ, the predominant isoform of the ER expressed in platelets. It has been said that suppression of free testosterone levels by ERα activation-induced increase in hepatic sex hormone-binding globulin production is the primary mechanism of action of GTx-758 in the treatment of prostate cancer. GTx-758 is a diphenyl benzamide and has a similar structure to stilbestrol derivatives like diethylstilbestrol and triphenylethylene derivatives like chlorotrianisene. In animal studies, GTx-758 reversibly suppresses testosterone concentrations to castrate levels, reduces prostate size and levels of prostate-specific antigen, but does not induce typical side effects associated with hyperestrogenism including hot flashes, bone loss, hypercoagulation, or increased body fat.

Unlike diethylstilbestrol, GTx-758 does not induce gynecomastia in male monkeys, despite suppressing testosterone levels to the castrate range and markedly reducing PSA levels. In a phase II clinical trial of 1000 mg/day and 2000 mg/day GTx-758 versus leuprorelin for the treatment of prostate cancer, GTx-758 suppressed total testosterone levels to a lower extent than leuprorelin but decreased free testosterone and PSA levels to a greater extent, suggesting superior effectiveness. GTx-758 increased median SHBG levels by 495% and 583%, considered to account for the greater relative decrease in levels of free testosterone. There was a lesser incidence of estrogen deficiency-associated side effects in the GTx-758 group. For instance, there was a more than 4-fold lower incidence of hot flashes for GTx-758, C-terminal telopeptide and bone specific alkaline phosphatase levels increased in the leuprorelin group but decreased in the GTx-758 group, insulin-like growth factor-1 levels increased in the leuprorelin group but decreased in the GTx-758 group.

Incidence of gynecomastia was not reported with GTx-758. However, a higher incidence of venous thromboembolism was observed with GTx-78 relative to leuprorelin, this led to early termination of the clinical trial; the drug was said to be well tolerated aside from VTE. Studies are underway with lower doses of GTx-758 as secondary hormonal therapy in prostate cancer to see if such doses minimize the incidence of VTE. In a subsequent phase II clinical trial of 150 mg/day and 250 mg/day GTx-758 in castration-resistant prostate cancer, GTx-758 increased median SHBG levels by 301%, decreased free testosterone levels by median 44%, decreased PSA levels. To the prior phase II clinical trial, GTx-758 was regarded as well tolerated, improved bone parameters, but there were still two drug-related severe adverse effects. List of investigational hormonal agents § Estrogenics 16α-LE2 ERA-45 ERA-63 Propylpyrazoletriol GTx-758 - AdisInsight Pipeline - GTx

Faculty of Science, University of Zagreb

Faculty of Science is one of the faculties of the University of Zagreb. The Faculty of Science of the University of Zagreb was established in 1946, although teaching started in 1876; the faculty comprises seven departments, the seismological service, the mareographic and meteorological stations, the Zagreb Botanical Garden. The Faculty has 288 full professors and assistant professors, 180 junior researchers and about 6000 students; the Faculty offers undergraduate and postgraduate study programmes, pursues research in the fields of natural sciences and mathematics. The Faculty of Science is engaged in excellent cooperation with numerous universities and institutes abroad. Professors of the Faculty have been invited as visiting lecturers to European and American universities, young staff members, as well as postgraduate students, are sent to international universities and institutes for further research. On 23 September 1669. Leopold I certified at the Jesuit Neoacademica Zagrebiensis, a three-year higher education institution, which developed the studies of Philosophy and Theology.

At the Jesuit School philosophy was taught earlier, part of its first year studies were logic and metaphysics. Neither Jesuit School, nor royal Regia Scientiarum Academica represented a real university. Croatian Parliament and Franz Joseph I of Austria, introduced the Law on founding the University of Zagreb. Soon after the establishing of the University of Zagreb, Faculties of Law and Philosophy started operating; the Chairs of the Faculty of Philosophy were appointed gradually. In the field of natural sciences the teaching started in 1876, with first lectures in mineralogy and geology, in botany, mathematics and zoology and geography. A long endeavour of the Science Department of the Faculty of Philosophy to attain the status of Faculty materialized in 1946, when the Faculty of Science was established; the Faculty consists of following departments: Department of Biology Department of Physics Department of Chemistry Department of Mathematics Department of Geophysics Department of Geography Department of Geology Department of Geography at the Faculty of Science in Zagreb is the oldest and the biggest geographic department in Croatia.

The Department of Geography consists of three divisions: physical geography, human geography, regional geography and teaching methods. The Cartographic-technical Centre with a rich Cartographic Collection and the Central Geographic Library are part of the Department, it was founded on 27 December 1883 by Petar Matković. In 1927 Institute for physical geography is being established within the Department and twenty years incorporated in the newly established Faculty of science. Central geographical library was opened in 1910 and, until 1994 it was the only geographical library in Croatia. Professor Ivan Crkvenčić launched Geographical papers scientific journal, still being released, as well as Acta Geographica Croatica; the Faculty of Science has eight undergraduate study programmes encompassing 3 years of studies, 26 graduate study programmes encompassing two years of studies or five years of studies and seven postgraduate study programmes encompassing 3 years of studies. Education is at all levels characterized by teaching and supervision at a high academic level by staff involved in research.

Departments of the Faculty are placed on several locations in Zagreb. The Departments of Physics, Geophysics, Chemistry and the main administration of the Faculty are set at Horvatovac where a "campus of science" is being built. Departments of Biology and Geography are going to be set at the same location in the near future; the education of students in science and mathematics is a part of a comprehensive science education that qualifies them to work in research institutes, different branches of industry and production, the civil service, public institutions and elsewhere, or as teachers in primary and vocational schools. Bachelor of Science programmes: Biology, Mathematics, Molecular Biology, Geology, Environmental Science. Master of Science programmes: Applied Mathematics, Computer Science and Mathematics and Conservation, Environmental Science, Experimental Biology and Business Mathematics, Geology, Mathematics, Mathematical Statistics, Molecular Biology, Pure Mathematics. Master of Education programmes: Chemistry and Computer Science, Geography.

Master of Science programmes: Physics. Master of Education programmes: Biology and Chemistry and History, Mathematics and Physics, Physics and Chemistry, Physics and Computer Science and Technology. Faculy offers PhD degree programmes. Dr. Tanja Bosak – professor at Massachusetts Institute of Technology Arsen BaukMinister of Public Administration Mladen Bestvina – professor at University of Utah Jakša Cvitanić – professor at California Institute of Technology Silvija Gradečak, PhD – professor at Massachusetts Institute of Technology Dragan Miličić – professor at University of Utah Dr. Aleksandra Radenović – professor at École Polytechnique Fédérale de Lausanne Dr. Ana Sunčana Smith – professor at Univ

Rowland Parker

Rowland Parker was an author and social historian. His 1975 work, The Common Stream, has achieved recognition as a classic of social history. Parker was born in 1912 in North Lincolnshire, his father and great-grandfather were all farmers and his youth was spent in the country. He was educated at Louth Grammar School, won a scholarship to the University of Nottingham and trained as a teacher. In 1935 he joined the staff of what was the Central School, and, except for the war, remained there until his retirement in 1972, he enlisted in the Royal Artillery in 1940, serving in North Africa, Egypt and Palestine, where he began to take an interest in archaeology and history. After the war, he moved to Foxton, remained there until his death in 1989, he became known as a notable local figure after The Common Stream increased the village's national profile. Cottage on the Green The Common Stream On the Road: The Papworth Story Men of Dunwich: The story of a vanished town Town and Gown: Seven hundred years' war in Cambridge