Comerica Bank Tower is a 60-story postmodern skyscraper located at 1717 Main Street in the Main Street District in downtown Dallas, Texas. Standing at a structural height of 787 feet (240 m), it is the third tallest skyscraper in the city of Dallas. It is also the sixth tallest building in Texas and the 61st tallest building in the United States. The building was designed by Philip Johnson and John Burgee, and was completed in 1987. The structure has 1,500,000 square feet (100,000 m2) of office space.

The Main Street District of downtown Dallas, Texas runs along Main Street and is bounded by Elm Street one block north, Commerce St. one block south, N. Lamar St. to the west, and US 75/I-45 (I-345) elevated highway to the east. The district is the spine of downtown Dallas, and connects many of the adjoining business and entertainment districts. It does not include Dealey Plaza or the John Fitzgerald Kennedy Memorial which are a few blocks west in the West End Historic District.