Comiso is a comune of the Province of Ragusa, Sicily, Southern Italy. As of 2017, its population was 29,857.

The province of Ragusa was a province in the autonomous region of Sicily, Italy, located in the southeast of the island. Following the abolition of the Sicilian provinces, it was replaced in 2015 by the free municipal consortium of Ragusa. Its capital is the city of Ragusa, Sicily, which is the most southerly provincial capital in Italy.