Commercial Resupply Services (CRS) are a series of flights awarded by NASA for the delivery of cargo and supplies to the International Space Station (ISS) on commercially operated spacecraft. The first CRS contracts were signed in 2008 and awarded $1.6 billion to SpaceX for twelve cargo Dragon and $1.9 billion to Orbital Sciences for eight Cygnus flights, covering deliveries to 2016. The Falcon 9 and Antares rockets were also developed under the CRS program to deliver cargo spacecraft to the ISS.

Dream Chaser is an American reusable lifting-body spaceplane developed by Sierra Space. Originally intended as a crewed vehicle, the Dream Chaser Space System is set to be produced after the Dream Chaser Cargo System cargo variant is operational. The crewed variant is planned to carry up to seven people and cargo to and from low Earth orbit.