Commissioner Street is a major one-way street (westwards) in the Central Business District of Johannesburg, South Africa. It runs from the M31 to the R41, and is indicated as the R24. The Carlton Centre, the 2nd-tallest building in Africa, is located on the street, as is the southern end of Newtown. There is little evidence of Commissioner Street's exact origin, although it is known that this street played a role in the development of Johannesburg.

The R24 is a major East-West provincial route in the Gauteng and North West provinces that links OR Tambo International Airport with Rustenburg via Johannesburg, Krugersdorp and Magaliesburg. The process of renaming the streets and freeway that form the route from Krugersdorp eastward to OR Tambo International after anti-apartheid stalwart Albertina Sisulu was completed in 2013.