The Compton Gamma Ray Observatory (CGRO) was a space observatory detecting photons with energies from 20 keV to 30 GeV, in Earth orbit from 1991 to 2000. The observatory featured four main telescopes in one spacecraft, covering X-rays and gamma rays, including various specialized sub-instruments and detectors. Following 14 years of effort, the observatory was launched from Space Shuttle Atlantis during STS-37 on April 5, 1991, and operated until its deorbit on June 4, 2000. It was deployed in low Earth orbit at 450 km (280 mi) to avoid the Van Allen radiation belt. It was the heaviest astrophysical payload ever flown at that time at 16,300 kilograms (35,900 lb).

A gamma ray, also known as gamma radiation (symbol γ), is a penetrating form of electromagnetic radiation arising from the radioactive decay of atomic nuclei. It consists of the shortest wavelength electromagnetic waves, typically shorter than those of X-rays. With frequencies above 30 exahertz (3×1019 Hz) and wavelengths less than 10 picometers (1×10−11 m), gamma ray photons have the highest photon energy of any form of electromagnetic radiation. Paul Villard, a French chemist and physicist, discovered gamma radiation in 1900 while studying radiation emitted by radium. In 1903, Ernest Rutherford named this radiation gamma rays based on their relatively strong penetration of matter; in 1900, he had already named two less penetrating types of decay radiation (discovered by Henri Becquerel) alpha rays and beta rays in ascending order of penetrating power.