The Conrad Weiser Homestead was the home of Johann Conrad Weiser, who enlisted the Iroquois on the British side in the French and Indian War. The home is located near Womelsdorf, Berks County, Pennsylvania in the United States. A designated National Historic Landmark, it is currently administered as a historic house museum by the Pennsylvania Historical and Museum Commission. The historic site was established in 1923 to preserve an example of a colonial homestead and to honor Weiser, an important figure in the settlement of the colonial frontier.

Conrad Weiser, born Johann Conrad Weiser, Jr., was a Pennsylvania Dutch (German) pioneer who served as an interpreter and diplomat between the Pennsylvania Colony and Native American nations. Primarily a farmer, he also worked as a tanner, and later served as a soldier and judge. He lived part of the time for six years at Ephrata Cloister, a Protestant monastic community in Lancaster County.