Constantine is a village in St. Joseph County in the U.S. state of Michigan. The population was 2,076 at the 2010 census. The village is located within Constantine Township. U.S. Highway 131 leads to Kalamazoo to the north and to the Indiana Toll Road six miles to the south. The St. Joseph River, navigable from source to outlet, passes through the village, emptying in Lake Michigan to the west.

St. Joseph County is a county located in the U.S. state of Michigan, on the central southern border with Indiana. As of the 2020 United States Census, the population was 60,939. The county seat is Centreville.