The Consulate General of United States, Guangzhou is one of seven American diplomatic and consular posts in China. It is one of America's earliest diplomatic posts in the Far East. The consulate serves the South China region, covering the provinces of Guangdong, Hainan and Fujian, and the Guangxi Zhuang Autonomous Region, an area which, according to the latest census in 2020, has a resident population of over 220 million. The consulate general is also the only U.S. mission in mainland China to process American adoptions and immigrant visas, making it one of the U.S. Department of State’s busiest consular-related posts.

Shamian is a sandbank island in the Liwan District of Guangzhou, Guangdong, China. The island's name literally means "sandy surface" in Chinese.